He is an accomplished concert pianist, music composer and singer with a command of Indian and Western classical/semi-classical music, jazz, rock and pop music. Burman concert in London, and encouraged him to take up music as a career. Indian singer Asha Bhosle saw him at age ten at an R. Sami began taking lessons in Indian classical music from the santoor maestro Pandit Shivkumar Sharma when visiting India during his school vacations. He had played the piano since the age of five and composed his first piece of music when he was nine years old. He went on to qualify as a barrister from Lincoln's Inn, England. Adnan followed his bachelor's degree with a law degree ( LLB) from King's College London. Sami attended Rugby School in Rugby, West Midlands, UK. Agha Mehfooz Jan was assassinated by Habibullah Kalakani and therefore Sami's father's family migrated to Peshawar, then in British India. His paternal great-grandfather Agha Mehfooz Jan was the governor of four Afghan provinces under King Amanullah Khan's reign and was also the King's first cousin, while his paternal grandfather Abdul Sami Khan served as the Deputy Inspector General of Police.

His paternal great-great-grandfather, General Ahmed Jan, was from Afghanistan and a military advisor to king Abdur Rahman Khan. Adnan's father served as a Pakistan Air Force pilot, before becoming a senior bureaucrat and serving as Pakistan's ambassador to 14 countries. His father, Arshad Sami Khan, was a Pakistani Pashtun while his mother Naureen Khan was an Indian from Jammu. He was raised and educated in the United Kingdom. Sami was born in London, England on 15 August 1971. He was awarded the Padma Shri on 26 January 2020. The Times of India has called him the 'Sultan of Music'.

He was born to Arshad Sami Khan, a Pakistani Air Force veteran and diplomat of Pashtun origin, and Naureen, who was originally from the Indian state of Jammu and Kashmir. He was raised and educated in the United Kingdom and spent his life in Canada.

A review in the US-based Keyboard magazine described him as the fastest keyboard player in the world and called him the keyboard discovery of the nineties. He has been credited as 'the first musician to have played the santoor and Indian classical music on the piano'. His most notable instrument is the piano. He has been awarded with Padma Shri (India's fourth highest civilian award) for his remarkable contribution in music. He performs Indian and Western music, including for Hindi movies. Adnan Sami Khan (born 15 August 1971) is an Indian singer, musician, music composer, and pianist.

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